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When side effects outweigh benefits, stopping makes sense

Retatrutide's 104-week extension data suggests a later plateau consistent with the glucagon mechanism's ongoing metabolic effects

They will also need to determine whether the apparent benefit is unique to GLP-1 receptor agonists or reflects a broader effect of improved metabolic control
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In T2DM patients, insulin cannot regulate hepatic glycogen synthesis or glucose production, and increased hepatic gluconeogenesis is the primary cause of fasting hyperglycemia in T2DM [25]
