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C., Kashkouli, A., Liu, Z
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Amitriptyline can also affect blood sugar, with its SmPC noting it may modify insulin and glucose responses

But, they are different in some important ways

Increased heart rate is a commonly observed effect, typically averaging 2-4 beats per minute above baseline

This may be of benefit for anyone with MCAS, and clinical trials are looking at the effectiveness of different doses.[ref][ref] Dementia prevention: Studies using data from diabetes patients showed a significant decrease in dementia for those on GLP-1s vs other diabetes medications
