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Dietary patterns that support GLP-1 biology may also help people tolerate GLP-1 receptor agonist (GLP-1RA) therapy by reducing gastrointestinal side effects, which are a frequent reason for discontinuation in clinical practice

This rapid turnover means that maintaining therapeutic levels of GLP-1 activity requires either continuous endogenous production or pharmaceutical intervention with DPP-4-resistant analogs

Early medications that simply boosted natural incretin levels had limited effectiveness because the hormones still degraded quickly

J Clin Endocrinol Metab 99(7):24772485

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