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The mice were sacrificed by cervical dislocation at 5, 15, 30, 60, 150, and 360 min after administration (n = 4 for each time point), followed by immediate resection of each organ including the pancreas, kidney, liver, spleen, lung, and blood

Additionally, the lack of imbalance in the PASADENA trial in the proportion of events reached prior to starting symptomatic therapy between treatment groups (97% in placebo-treated group and 96% in the prasinezumab-treated group) could potentially influence the relative robustness of the TTE and MMRM approaches in future trials

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