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27 At the 1-, 2-, and 3-year timepoints, they found that the GLP-1 RA cohort had a significantly lower risk of all three outcomes compared with metformin users

Serious adverse events were relatively rare, but they did happen

In the STEP 1 trial, of the average 13.6kgweight reduction, 8.3 kg (62%) was fat mass and 5.3 kg (38%) was lean body mass (including muscle and other nonfat tissues) [14]

If you're feeling sluggish or lightheaded, drinking water can help restore your energy levels

Injectable GLP-1s may be more suitable for: Patients aiming for the maximum possible reduction in body weight, those with co-existing conditions like heart disease or chronic kidney disease (due to specific FDA approvals for Ozempic), or those who prefer a simple weekly medication schedule

Davies MJ, Bergenstal R, Bode B, Kushner RF, Lewin A, Skjoth TV et al (2015) Efficacy of liraglutide for weight loss among patients with type 2 diabetes: the SCALE diabetes randomized clinical trial