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The STEP trials demonstrated that participants lost an average of 10-15% of their body weight over 68 weeks, depending on lifestyle adherence and consistency with medication

This suggests that aged pancreatic islet cells were unable to produce endogenous MOTS-c in response to H 2 O 2 -induced senescence (Fig

Patients with severe gastrointestinal disease, including gastroparesis, may not tolerate the medication well

Variants in the GLP1R gene, particularly rs6923761, correlate with differences in receptor expression and signaling efficiency

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