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Persistent stimulation leads to receptor desensitization

found that intraperitoneal injection of exendin-4 increased the number of BrdU-positive progenitor cells in the subventricular zone (33), indicating that exendin-4 could compensate for the loss of dopaminergic neurons in the PD model by promoting the formation of substantia nigra neurons

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Hum Mol Genet 18:23882399 Villareal DT, Robertson H, Bell GI et al (2010) TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action

McGuire DK, Busui RP, Deanfield J et al

Normal thirst resolves when you drink fluids
