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Search tools, saved lists, and category shortcuts minimize friction and unlock the fun part: choosing the next round to play, whether that means a classic card table or a fresh seasonal release

Published online December 8, 2025
In a large phase 3 obesity trial (ACHIEVE-1), orforglipron at daily doses of 3, 12 and 36 mg caused approximately: Diarrhoea: 1926% of participants (vs 9% on placebo) Nausea: 1318% (vs 2% on placebo) Constipation: 817% (vs 4% on placebo) Vomiting: 514% (vs 1% on placebo) Across multiple studies, 617% of people stopped treatment because of side effects, mostly gut-related symptoms
This study explored the role of the GLP-1 signaling pathway from NTS to BLA and the impact of Exendin-4 on anxiety and depression-like behaviors in mice undergoing heroin withdrawal

Both LEADER and SUSTAIN-6 had a prespecified composite renal outcome of new or worsening nephropathy consisting of new onset of persistent macroalbuminuria, persistent doubling of serum creatinine level and eGFR 45 mL/min/1.73 m 2 , need for continuous RRT (in absence of an acute reversible cause), and renal death

10.1007/s44337-025-00241-9 [DOI] [Google Scholar] 34
