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and phase-advances diurnal rhythms of feeding and metabolism into the light cycle, and abolishes the normal increase in dark-cycle locomotor activity [27]

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We use these to establish a robust relationship between GLP-1R trafficking and insulin release in a manner not predicted by the standard pharmacological potency testing for cyclic adenosine monophosphate (cAMP), a primary second messenger coupling GLP-1R activation to insulin secretion 13

It is also FDA approved to reduce cardiovascular risk in adults with Type 2 diabetes who are at high risk

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