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This is particularly important following dose increases

The majority of circulating biologically active GLP-1 is found in the GLP-1(7-36) amide form), but a lower concentration of the GLP-1 (7-37) form is detectable

Patients with kidney disease may require modified protein goals under medical supervision

OliveiraFCBBauerEJRibeiroCMPereiraSABeserraBTSWajnerSMet al

Important safety considerations include a boxed warning regarding thyroid C-cell tumors observed in rodents (though the relevance to humans is unknown) and contraindications for patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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