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However, the role of GLP-1R in the pathological process of OA is unclear

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Conclusions Hypomorphic PAM T2D-risk alleles reduce amidating enzyme activity, elevate circulating GLP-1 levels, and impair GLP-1 post-receptor signaling, culminating in a selective and clinically meaningful reduction in GLP-1RA efficacy

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Understanding response variabilityinformed by biomarkers and genetic contextcan help guide conversations with healthcare providers about optimization strategies