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Interestingly, GLP-1/GLP-2 co-agonists have recently been reported to have greater glycemic and intestinotrophic effects compared to the GLP-1 receptor agonist, liraglutide 26

Moreover, to evaluate the responsiveness of the GRS to changes in glucose levels, the system was exposed to glucose concentrations which increased from 100 to 400 mg dl 1 , or periodically switched between 100 and 400 mg dl 1 at 1 h intervals

Neuroscientific knowledge and shared mechanisms of AUD and obesity Both AUD and obesity are characterized by compulsive consummatory behaviors that persist despite adverse consequences, at least partially consistent with intersecting neurobiological mechanisms [33, 52]

Animal studies have demonstrated that GLP-1 receptor activation can reduce preference for palatable, high-sugar foods and decrease reward-driven eating behaviours