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In the STEP 1 extension, participants regained around two-thirds of the weight lost within a year of stopping semaglutide, returning to a ~5.6% net loss over two years

This difference in regulation is important when deciding which treatments are safe to rely on for long-term weight management

If anaphylaxis or severe allergic reaction is suspected, the medication should be discontinued immediately

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- 707145 - 06/06/2025 - Warning Letters - FDA, accessed December 30, 2025, CCIC Huatongwei International Inspection Co., Ltd

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