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BMI body mass index, CVOT cardiovascular outcome trial a P effect , P -value for test effect b P hetero , P -value for between-subgroup heterogeneity C Only studies of albiglutide, dulaglutide, liraglutide, and semaglutide (oral and subcutaneous) had different treatment doses (a single trial may have one or more dose sizes) d The cut-off point was 32.38 kg/m 2 (mean baseline BMI in all included trials except 2 trials without reporting data on baseline BMI) e Random effects model were used to calculate the estimates because of the high heterogeneity Atrial flutter A total of 57 patients treated with GLP-1 RAs experienced AFL (n = 30,223), whereas 63 individuals in the control group (n = 26,333)

Additionally, the magnitude of peripheral metabolic effects, like insulin secretion, glucagon suppression, and modulation of gut hormones, can also be influenced by a patients existing metabolic status and degree of insulin resistance [29,30]

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