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Although we did not expect SEM to cross the BRB, we anticipated that its retinal effects likely arise from indirect signaling via the CVOs or peripheral pathways, such as the increased vascular permeability associated with this OHT model [20]

Clinicians should emphasize that lifestyle changes, particularly dietary quality and eating patterns, remain important even when structured exercise is not feasible

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Individualized titration may be necessary for patients experiencing significant nausea