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Compared with placebo, tirzepatide provided an additive body-weight loss of 11.9%, 16.4% and 17.8% with an increasing dose of 5 mg, 10 mg and 15 mg, respectively, and 83.5% of participants in the 15 mg group had 10% body-weight loss [28]

As clinical trials progress and regulatory approvals are sought, these therapies have the potential to redefine obesity management and improve patient outcomes worldwide

Weight loss reduces aromatase activity (meaning less conversion of testosterone to estrogen) and often improves testicular and ovarian function

J Immunol 179: 5839-5844

J Endocrinol (2009) 202(3):4319

Metabolic Health and Glucose Homeostasis : GLP-1 R is central to studies on metabolic disorders such as insulin resistance , pre-diabetes , and metabolic syndrome , where it is used to understand how GLP-1 receptor activation improves insulin sensitivity and glucose metabolism