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Proc Natl Acad Sci 97:68746879

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doi: 10.1152/ajpendo.00429.2014

Sometimes this step can lead to unexpected coverage for the medication if your doctor provides strong supporting documents regarding your health and financial status

Central Appetite Regulation: Activation of GLP-1 receptors in the hypothalamus and brainstem decreases hunger and food intake

Contraindications: As per the US licence, I would regard tirzepatide as contraindicated in people with a personal or family history of medullary thyroid carcinoma (MTC) and in those with multiple endocrine neoplasia syndrome type 2 (MEN 2)