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Tirzepatide activates two: GLP-1, which slows digestion and helps regulate appetite, and GIP, which influences how your body responds to insulin and stores energy

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Endothelial dysfunction is a significant component of HFpEF pathophysiology, and glucagon-like peptide-1 receptor (GLP-1R) agonists have shown potential benefits in improving endothelial function

Smaller meals, hydration, slower dose increases, and better timing can often reduce it.

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