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The HARMONY Outcomes CVOT (which only included subjects with established CVD) similarly showed a 22% CV risk reduction with albiglutide vs placebo (hazard ratio 0.78) [37], and the REWIND CVOT showed an identical 13% effect size across subgroups with and without established CVD (hazard ratio 0.87) [38]

doi: 10.1016/S0031-9384(01)00612-6 21 DavidsenLVistisenBAstrupA

Additionally, psychological factors including emotional eating patterns, restrictive dieting history, and stress can amplify food noise

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These reports align with the clinical trial data showing that the majority of weight loss occurs at the 5 mg dose level, with diminishing returns at higher doses relative to the increased side effect burden