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This integrated approach enables synergistic glucose-lowering and weight reduction effects that exceed those achieved by selective incretin agonism alone

Several potentially modifiable risk factors in midlife, particularly metabolic factors (diabetes mellitus, hypertension, obesity, and low HDL cholesterol), hearing loss, traumatic brain injury, and alcohol abuse, are associated with an increased risk of later-life dementia [150]

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The body composition substudy The Lancet Diabetes and Endocrinology published a substudy specifically examining body composition changes using DXA scanning, the gold standard for measuring fat versus lean mass

Retatrutide adds glucagon receptors to the GLP-1/GIP target list and could be the first type 2 diabetes agent to directly improve liver disease

TRIUMPH-2: NCT05931367