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GLP-1 receptor agonists were first approved by the Food and Drug Administration (FDA) for the treatment of type 2 diabetes

Lancet 397(10278):971984 [DOI] [PubMed] [Google Scholar] 20.Shi I, Khan SS, Yeh RW, Ho JE, Dahabreh IJ, Kazi DS (2025) Semaglutide Eligibility Across All Current Indications for US Adults

When tested as a once-daily injection in single and multiple doses varying up to 0.18 mg in healthy normal to overweight volunteers, gastrointestinal adverse events (nausea, diarrhoea, constipation, vomiting) were encountered, but the drug was described as well tolerated

Self-monitoring carbohydrate intake, either through counting or estimation, is important for glycemic control [227]

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