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There were very few drugs licensed for weight loss.and those that were had unacceptable side effects, didnt use healthy weight-loss principles or just didnt work well enough

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These work in a similar way to Wegovy, as weekly injections that help patients feel full (decreasing food noise and encouraging weight loss alongside a low-calorie diet and increased exercise)

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We also discuss combination therapies and strategies to mitigate muscle mass loss during treatment and calls for targeted research, improved clinical education, and policy reforms to optimize the translational potential of GLP-1R agonists in both individualized care and population health