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CSF is primarily produced by the choroid plexus within the lateral ventricles and flows sequentially through the third and fourth ventricles to reach the subarachnoid space

Diabetes 63:24862497 Nauck MA, Petrie JR, Sesti G et al (2016) A phase 2, randomized, dose-finding study of the novel once-weekly human GLP-1 analog, semaglutide, compared with placebo and open-label liraglutide in patients with type 2 diabetes

In animal models, GLP-1RAs inhibited myocardial fibrosis and reduced ventricular hypertrophy

Tirzepatide (Mounjaro and Zepbound) produces larger total weight loss than semaglutide on average, which means larger absolute muscle loss in numbers, even if the proportional loss is similar

However, the one-month latency was atypical, as true AGEP typically appears within days [9]

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