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Additional hypotheses include the rapid correction of glycemia following GLP-1 RA administration, similar to the exacerbation of DR, as well as long-term effects of prior hyperglycemia via persistent changes in endothelial gene expression, often referred to as glucose memory [198,199]
This has subsequently been taken forward into Phase 1 clinical trials as ALT-801 ( Table 1 )
doi:10.1007/s13300-020-00981-0 21
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+5.9 7.2 nmol/L with TRT), with comparable improvements in sexual function, including libido and erectile performance
