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Implications for Glucagon Family Receptor Poly-Agonists: GLP-1R Agonism Is Sine Qua Non Over the past few years, novel class B1 GPCR poly-ligands, i.e., compounds that bind more than one receptor simultaneously, have joined the ranks of the classic GLP-1RAs (GLP-1R mono-agonists), such as exenatide, liraglutide, semaglutide, dulaglutide, etc

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And thats where Topamax steps in, the topic for todays conversation