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Patients are randomized to 2.5 to 5 years of weekly semaglutide injections or placebo as an adjunct to standard care

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d-Allulose Inhibits Ghrelin-Responsive, Glucose-Sensitive and Neuropeptide Y Neurons in the Arcuate Nucleus and Central Injection Suppresses Appetite-Associated Food Intake in Mice

These treatments could broaden adoption by appealing to patients who prefer to avoid injections and by enabling more scalable manufacturing

Biogen will need to address these documentation requirements before the application can be reconsidered