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Description
This context-dependent reprogramming explains why tirzepatide, unlike isolated GIP exposure, produces net reductions in subcutaneous and visceral fat even in insulin-sensitive phenotypes such as early-stage lipedema

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Int Immunopharmacol 135:112308 Holahan MR (2017) A shift from a pivotal to supporting role for the growth-associated protein (GAP-43) in the coordination of axonal structural and functional plasticity

The biggest distinction is how theyre takenliraglutide requires a daily injection, while tirzepatide is once-weekly
