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That's lower than the 7.1% discontinuation rate seen with semaglutide 2.4 mg in the STEP trials, suggesting tirzepatide is better tolerated at maximum doses despite the higher absolute milligram amount

This moment demands informed, culturally grounded responses rather than surface-level reactions. Once largely confined to medical settings, GLP-1 treatments now sit at the intersection of science, culture, and daily life, reshaping conversations around nutrition, identity, and personal agency

10.1016/S0140-6736(21)01324-6 83 RosenstockJ.FriasJ.JastreboffA

They ensure its not interacting with other medications you take

your starting weight, how long you stay on the medication, the dose you reach, and the lifestyle changes you make alongside treatment can all affect how much weight you lose

The value of the graph is that it lets you see the longer-term trend, he explained