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(2) Long-acting GLP-1 receptor agonist: This class of receptor agonists is characterized by consistently high drug concentrations that fall within a range that allows for substantial GLP-1 receptor stimulation with negligible inter-injection variations

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The distinct contributions of each receptor system - GLP-1-mediated improvements in insulin sensitivity and appetite regulation, GIP-mediated enhancement of insulin secretion and adipose tissue function, and glucagon-mediated direct hepatic metabolic modulation and increased energy expenditure - create synergistic benefits when engaged through dual or triple agonist formulations