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Preclinical studies have demonstrated that DPP-4 inhibitors significantly prevent the onset of liver cancer in MC4R-KO mice [111]
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are novel glucose-lowering agents that activate GLP-1 receptors leading to blood glucose reduction, postprandial glucose metabolism improvement, and gastric emptying delay (2)
Differences in the glucose-lowering efficacy of dipeptidyl peptidase-4 inhibitors between asians and non-asians: A systematic review and meta-analysis
(2016) 311:R12432
All animal studies, including the EMA and FDA records, had a high risk of bias ( Supplement 7 )
