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Hypoglycemia (low blood sugar levels) is more frequent if used in combination with other medicines to lower the blood sugar or if taken in excess of the recommended dose

The other salient reason is that various receptors crosstalk with each other, thereby affecting each others cAMP producing capacity

Glucagon receptor activity and energy-expenditure pathway research

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[DOI] [PubMed] [Google Scholar] 206.Wadden TA, Hollander P, Klein S, Niswender K, Woo V, Hale PM, Aronne L
