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ActRII inhibition drives skeletal muscle hypertrophy and preserves muscle mass during weight loss induced by GLP-1 receptor agonism In the same cohort of mice, we evaluated the effect of GLP-1 receptor agonism and ActRII blockade on individual tibialis anterior (TA), soleus, extensor digitorum longus (EDL), and gastrocnemius muscles

These factors include the patient's weight loss goals, overall health status, and response to the drug

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While nausea, vomiting, and diarrhea are the most commonly reported gastrointestinal adverse effects with GLP-1-based therapies (occurring in 15-40% of patients depending on the agent and dose), FDA prescribing information for several of these medications does list dyspepsia (indigestion) and, in some cases, gastroesophageal reflux disease (GERD) as reported adverse reactions

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