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295 milliosmoles/L) containing (in mM): 138 NaCl, 5.6 KCl, 2.6 CaCl 2 , 1.2 MgCl 2 , 10 HEPES (adjusted to pH 7.4 with NaOH), and supplemented with 11.1 mM glucose, 20 l ml 1 FBS, 1 l ml 1 Pluronic F-127, and 1 M fura-2 acetoxymethyl ester (fura 2-AM

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Like any medication, oral semaglutide may cause side effects, although not everyone will experience them

The main side effects complained of by patients were generally mild and mostly transient, and their hierarchical distribution is shown in Figure 6

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Normalizing for time, retatrutide produces approximately 0.5% body weight loss per week at its highest dose, compared to roughly 0.25% for semaglutide and 0.31% for tirzepatide