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(5.3) Tolerance to the anorectic effect usually develops within a few weeks

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Appetite suppression often becomes stronger as the dose is gradually increased

[DOI] [PubMed] [Google Scholar] 97.Zelniker T.A., Wiviott S.D., Raz I., et al

Notably, given that SGLT-2 is expressed in the brain, which is consistent located with enhanced cFos expression induced by SGLT-2is, we hypothesize that SGLT-2is may cross the BBB via receptor-mediated transcytosis