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Description
They bind to GLP-1 receptors in the pancreas, brain, and GI tract to increase insulin secretion, suppress glucagon, slow gastric emptying, and signal satiety to the hypothalamusresulting in reduced caloric intake and significant weight loss over time
Until now, all GLP1 options for weight loss required injections
To meet this demand, some health systems have created weight-management clinics that have medical oversight from the health system but are staffed by mid-level providers or pharmacists
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Historically, neuropathy endpoints were not primary outcomes in major diabetes trials
Early evidence suggests it is generally well-tolerated, with most side effects being mild to moderate gastrointestinal symptoms (such as nausea, diarrhoea, or constipation)
