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[DOI] [PubMed] [Google Scholar] 6.Flint A, et al

in the early 2020s

A historical reason is that DPP-4 inhibitors were introduced in 2006 and therefore, the practical experience with this class of agents is deeper and more widespread than that with SGLT-2 inhibitors
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4Reed J, Bain S, Kanamarlapudi V

They show proof of concept and only involved a small number of mice, but the findings gave him optimism that the treatment is worth investigating
