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Patient-specific factors that may increase risk include recent dose escalation, higher doses, significant gastrointestinal symptoms, diabetes-related gastroparesis, and autonomic neuropathy
Chapter 23

As of early November, when Novo Nordisk and Eli Lilly announced deals with the Trump administration, the starting dose of Zepbound will be available for $299 a month for people buying without using insurance
PubMed abstract Predicting Non-Alcoholic Fatty Liver Disease for Adults Using Practical Clinical Measures: Evidence from the Multi-ethnic Study of Atherosclerosis

For patients with significant obesity or related conditions, that risk-benefit calculation tends to come out clearly in favor of treatment

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