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However, it is important to note that these studies were conducted in different countries and populations from this study

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Although the overall study findings were neutral, when patients enrolled in Russia and Georgia who likely did not have HFpEF were excluded, there was a significant reduction in the primary outcome among patients in the Americas

Combining these effects during active infection makes it harder to distinguish medication side effects from illness symptoms, complicates hydration status monitoring, and may prevent adequate caloric intake needed for immune function

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In fact, some patients may experience weight gain, as insulin facilitates the storage of glucose as fat when excess calories are consumed