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With the development of neuroimaging techniques, in vivo clinical studies substantiate the effects of GLP-1 on brain regions involved in the homeostatic and hedonic controls of energy balance

These side effects may become intolerable for some patients

It is a peptide molecule with a long duration of action, allowing for once-weekly subcutaneous injection in clinical practice

That matters on GLP-1 because the right next step is not always obvious from the scale alone

doi: 10.1016/j.bbrc.2009.10.054 41 Portela-GomesGMHoogA