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If your diabetes is already well controlled on metformin alone, adding berberine may not offer additional benefit and could increase the risk of hypoglycaemia or side effects

JAMA Ophthalmol , 2024 Aug 1;142(8):732-739

Rapid catabolism of glucose via glycolysis and mitochondrial TCA cycle activity generates ATP ( + channels, intracellular accumulation of K + ions and subsequent membrane depolarization, causing an influx of Ca 2+ via voltage dependent Ca 2+ channels (VDCC)

This question arises frequently as both substances address metabolic dysfunction through different mechanisms

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