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took another step toward adding a way for patients to hang onto their weight loss when the firm disclosed positive top-line data from the phase III Attain-Maintain trial with orforglipron, a once-daily oral small molecule GLP-1 receptor agonist

First introduced in 1927, insulin shock therapy was devised by Manfred Sakel, an Austrian neuropsychologist, after he observed an improvement in the psychiatric condition of one of his patients with a morphine addiction when he recovered from a hypoglycaemic coma accidentally induced by too much insulin

Do we still need more long-term data

Therefore, after successful phase III studies, 3 mg liraglutide was approved for obesity therapy [38]

We strive to provide the most effective, scientifically-backed treatments to our patients

10.1016/j.bmc.2021.116354 104 LambeirA