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The safety and glycaemic efficacy of tirzepatide as an additional treatment for Japanese subjects with T2D who were not achieving adequate glycemic control with various oral antihyperglycaemic monotherapies (SURPASS-J combo trial) were similar to those observed in the SURPASS-J mono trial [141]
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According to Riccardo Perfetti and colleagues from Cedars-Sinai Medical Center, Division of Endocrinology in Los Angeles, California, continuous infusion of GLP-1 to both young and old rats demonstrated an up-regulation of pancreatic-duodenum homeobox-1 (PDX-1) expression in islets and total pancreas which is essential for pancreogenesis, pancreatic cell differentiation, and maturation
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