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Ipamorelin also avoids spiking cortisol (stress hormone) and prolactin levels, making it one of the safest and cleanest peptides available

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The results indicate that there is a minor delay of gastric emptying during the early postprandial phase for subjects when treated with semaglutide, compared with placebo, but there is no overall effect on gastric emptying over a 5-h postprandial period [13]

10.1152/physrev.00025.2016 14