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After 29 weeks of diet induction (week-3 relative to start of treatment) a pre-treatment liver biopsy was performed as described in detail previously 44 to select animals for stratification and randomization based on histological assessment

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Front Endocrinol (Lausanne) 14:1240263 Sattar N, Neeland IJ, Dahlqvist Leinhard O, Fernandez Lando L, Bray R, Linge J et al (2025) Tirzepatide and muscle composition changes in people with type 2 diabetes (SURPASS-3 MRI): a post-hoc analysis of a randomised, open-label, parallel-group, phase 3 trial