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Having a backup plan, such as a well-insulated cooler with frozen gel packs in the freezer, ready to go at all times, can protect your medication during unexpected outages

Together, they promote optimal results

It is typically worst in the first few weeks after starting or increasing a dose and tends to improve significantly as the body adjusts to the medication

Clinical scenarios warranting consideration of GLP-1 therapy include: Type 2 diabetes management : Per ADA 2024 Standards of Care, GLP-1 RAs may be considered as initial therapy in patients with established atherosclerotic cardiovascular disease (ASCVD), high ASCVD risk, chronic kidney disease (CKD), or heart failure, or as add-on therapy when glycemic targets aren't met Established cardiovascular disease : Several GLP-1 receptor agonists have demonstrated cardiovascular risk reduction in patients with type 2 diabetes and established ASCVD Chronic kidney disease : While SGLT2 inhibitors are generally prioritized for CKD with type 2 diabetes when eGFR allows, GLP-1 RAs may provide complementary benefits Obesity with complications : When lifestyle interventions produce insufficient weight loss in patients with obesity-related comorbidities Important safety considerations include: Contraindications : Personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2

Slow down and chew thoroughly to allow your vagal nerve (which senses fullness) to kick in and help regulate appetite

Around a third of GLP-1 users who reduced their substance use (29%) took it a step further and quit entirely