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Avoid sudden, large drops in glucose by aiming for steady improvements

This is partly due to tirzepatide's mechanism of action as a double agonist, permitting it to assert a more significant decrease in hyperglycemia as compared to glucagon-like peptide (GLP-1) agonists on their own [8]

Khan MS, Fonarow GC, McGuire DK, et al

It is noteworthy that this superior effectiveness extended to primates (humans and cynomolgus monkeys) and rodent models of obesity and diabetes, such as db/db (diabetic) mice and Zucker diabetic fatty (ZDF) rat

The list of species and NCBI accession numbers, as well as the corresponding peptide sequences, are provided in Supplementary Tables 15 and 16

WhiteWBCannonCPHellerSRNissenSEBergenstalRMBakrisGLet al