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SNAC can non-covalently interact with peptide, forming a peptide/SNAC complex with increased lipophilicity able to permeate through the gastrointestinal epithelium via transcellular pathways [202]

TRIUMPH-1 extended the picture further: 28.3% at 80 weeks at the 12 mg dose, and 30.3% at 104 weeks in the extension group (participants with a BMI of 35 or higher a different subgroup, so the two figures are not a single continuous curve)

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29 Similar effects were observed with oral semaglutide in another crossover study in participants with T2D, also using the paracetamol absorption test

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