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Mnemonic: A BEAP Albumin (gm/dl) Bilirubin (mg/dl) Encephalopathy (Based on West Haven Criteria)

New trial data for Amgen's GLP-1 drug MariTide shows a weight loss of 20 percent in non-diabetic participants with obesity or overweight.

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(CNN) Starter doses of the weight-loss drug Zepbound are now available in single-dose vials, drug manufacturer Eli Lilly announced Tuesday,a move the company says willRead More

Although a recent meta-analysis showed an increased risk of GRC and aborted EGDs with GLP-1 RA use, it could not definitively establish a link to aspiration events due to limited data

Dosing Recommendations Based on phase 2 trials, the following dosing strategy has been employed: Starting dose: Typically 0.5 mg once weekly, with gradual increases Titration phase: Progressive increases to 1 mg, 2 mg, 4 mg, and potentially up to the maximum dose of 12 mg weekly Maintenance dose: Once the target or maximum tolerated dose is reached, patients continue at that level for ongoing treatment[8] Titration Strategy The gradual dose escalation approach serves several purposes: Minimizes gastrointestinal side effects through gradual adaptation Allows for monitoring of tolerability at each dose level Provides flexibility to pause or slow titration if side effects emerge Different starting doses (2 mg vs 4 mg) were tested, with lower starting doses showing better tolerability[4][8] Following the recommended titration schedule is crucial for maximizing patient adherence and treatment success