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Others see only a small shift, especially if they are building muscle or if hormonal water retention is present

The Bottom Line As researchers continue to explore the relationship between GLP-1 medications and muscle health, weight loss alone should not be the only measure of success

Retatrutide remains investigational and has not yet received FDA approval

These include bioactive compounds found in plants and foods, such as berberine, resveratrol, and polyphenols, which have shown promising potential in research

In a clinical trial published in the New England Journal of Medicine last year, people who were overweight or obese, but did not have diabetes, lost an average of 52 pounds on the highest dose of the drug, or more than 20% of their starting weight

The Precision Peptide Genetic Test reveals predispositions in peptide and metabolic pathwayssuch as GLP1R and FTO variantsthat relate to GLP-1 response and inflammatory status