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The substitution of Ala8 in GLP-1 by Gly8 in exendin-4 contributes to enhanced DPP-4 resistance ( Interestingly, until now, primarily long-chain peptides with 3339 amino acids have been developed as GLP-1RAs, which also carry a cost burden

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[DOI] [PubMed] [Google Scholar] 38.Jastreboff AM, Aronne LJ, Ahmad NN, et al

12 Furthermore, GLP-1RAs reduce the secretion of proinflammatory cytokines, namely interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-), which are often elevated in neuroinflammatory conditions like migraine